AVENIO Edge Liquid Handler

AVENIO Edge System
A differentiated liquid handler for automated NGS library prep

Simplify your NGS library prep with the AVENIO Edge System, a fully-automated IVD liquid handler for an end-to-end library preparation, target enrichment, quantification, normalization and pooling.

  • As little as 20 minutes of setup time
  • On-deck thermocycling and quantification
  • Ready-to-load barcoded reagent cartridges
  • Intuitive software and a glove-compatible touchscreen
  • No prior automation or NGS experience required

 

For more information, contact us.

Related information

AVENIO Edge System Use Cases

NGS library prep workflows are labor-intensive and time-consuming—especially if they include target enrichment (with oncology panels, for example). As a result, many genomics laboratories now rely on automated library preparation to streamline processes, reduce user-to-user variability, and improve reproducibility. 

However, many of the automated liquid handlers on the market are cumbersome to program, set up, and run. Now, with the AVENIO Edge Liquid Handling System, labs that have no prior experience with NGS or automation can easily run complex library prep workflows—freeing up hours of time for other projects and reducing errors that can occur with manual methods.

The AVENIO Tumor Tissue CGP Automated Kit: Powerful, precise, and proven with >5000 samples

AVENIO Tumor Tissue CGP Automated Kit enables laboratories to implement an end-to-end comprehensive genomic profiling (CGP) workflow without the daunting hurdles that could hinder discoveries. This end-to-end CGP workflow features a 335-gene panel aligned with the FoundationOne® CDx panel design, automated by the AVENIO Edge Liquid Handing System, and driven by the proven bioinformatics of the FoundationOne® Analysis Platform. With the expertise and proven technology of Roche and Foundation Medicine, labs can finally perform CGP with efficiency and renewed confidence.

View introductory video here > ~ 2 min

Customer Testimonials

Queen's University Belfast shares how AVENIO Edge System got their ACTIONED Project on track.

Reliable and Simple to Use

"Using the Avenio Edge System we can free up team members to work in different parts of the project, or even take [on] new projects that bring additional value. The AVENIO Edge System has played a vital role in making sure that we can keep our TAT in check."  Prof. David Gonzalez de Castro, PhD FRCPath

ctDNA Samples Analyzed Reliably

"The amount of the ctDNA that we have for each sample is very small. We therefore have only one opportunity to run the ctDNA on a library prep. With the AVENIO Edge we have the confidence and reliability that we can run ctDNA samples and [know] it will work."  Peter Stewart, PhD

Download the Case Study from Queen's University Belfast

Short Intro to AVENIO Edge Liquid Handler for NGS Library Prep and Target Enrichment

Watch this ~2 min video to learn about the capabilities and specifications of the AVENIO Edge Liquid Handler for NGS library prep and target enrichment. The AVENIO Edge provides an end-to-end library prep workflow, including cleanup steps, quantification, normalization, and pooling.

Comparing the AVENIO Edge System vs. other traditional liquid handlers

Watch this video to learn how the AVENIO Edge IVD Liquid Handling System helps make it easier for molecular pathology labs to prepare next-generation sequencing (NGS) libraries for applications such as cancer research, exome sequencing, and beyond.

Pioneering the Evolution of Human Genetics Research- Recap of ESHG 2024 Talk

Join Dr. Christian Betz, Ph.D, Head of Molecular Genetics at Bioscientia (part of Sonic Healthcare), for this recap of his ESHG 2024 presentation. In less than five minutes, Dr. Betz details how his lab established a high-throughput, cost-effective whole-exome sequencing (WES) workflow using an approach that has become the backbone for all next-generation sequencing (NGS) analysis at Bioscientia, one of Germany's largest human genetics laboratories.

To view the full video, click here

AVENIO Edge System Application Menu

View Full Table
close

AVENIO Edge System Application Menu

Here is a growing menu of workflows currently available on the system:

Here is a growing menu of workflows currently available on the system:

Workflow Maximum samples (Per Run) Estimated setup time (minutes)
AVENIO Edge HyperPrep or AVENIO HyperPlus DNA library preparation* 48 20
AVENIO Edge Target Enrichment with KAPA HyperExome or custom panels** 48 20
AVENIO Edge HyperCap DNA library preparation and target enrichment* 24 20
Input DNA quantification, normalization and buffer exchange 96 15
Post-capture pooling and quantification 48 15
*These workflows use UDI primers and universal UMI or non-UMI adapters.
**The input is indexed DNA or cDNA libraries

Prepare NGS libraries with no NGS or automation expertise

For true walk-away automated library prep, with 3 easy steps: CREATE the workflow, LOAD sample and reagents, and WALK AWAY.

True walk-away NGS sample prep automation

An overview of how the AVENIO Edge Automated Liquid Handler prepares NGS libraries, including target enrichment and pooling

AVENIO Edge System Deck Layout

A look inside of the AVENIO Edge Liquid Handler System for automated NGS library preparation
  1. Tip waste station
  2. Thermal cycler
  3. Heater/Shaker
  4. Magnetic separation station
  5. Plate and lid waste station
  6. Tip park
  7. Sample input station
  8. Sample output station

9.  Cooling unit

10. Tube racks

11. Piercing tool

12. Reagent mini racks

13. Reagent drawer

14.  P1000, P200, P50 Filtered tips

15. Quantification plate station

16. Consumable drawer

17. Gripper fingers exchange station

18. Quantification module

19. 2D Barcode reader

20. Processing plates

21. Processing plate lids

Download brochure
Clinical lab automation
Thinking of automating library prep on your existing liquid handler?

Roche’s NGS Automation Support Team, in collaboration with non-Roche liquid handling vendors, creates menus of automated methods for KAPA library prep reagents. Let’s talk about the next steps to get you up and running with automating your NGS library prep protocols. Visit support for non-Roche liquid handlers to learn more.

Support for automating KAPA reagents on non-Roche liquid handlers

Related Products

Customize, convert and modify protocol for laboratory-defined workflows on the AVENIO Edge System.
...
    ...

    AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

    View Full Table
    close
    Roche Cat. No.
    		 Description
    		                                                                                                  
    09283234001 AVENIO Edge Instrument   
    10001224001 AVENIO Designer Software SMP  
    View Full Table
    close

     

    Roche Cat. No.
    		 Description
    		 Kit Size
    09200860001 AVENIO Edge DNA HyperPlus Kit 3 x 8 reactions
    09200878001 AVENIO Edge DNA HyperPlus Kit 3 x 24 reactions
    09200886001 AVENIO Edge DNA HyperPrep Kit 3 x 8 reactions
    09200894001 AVENIO Edge DNA HyperPrep Kit 3 x 24 reactions
    09200908001 AVENIO Edge Target Enrichment, A 3 x 8 reactions
    09200916001 AVENIO Edge Target Enrichment, A 3 x 24 reactions
    09200924001 AVENIO Edge Target Enrichment, B 3 x 24 reactions
    09200959001 AVENIO Edge UDI Primer Mixes Plate 96 wells of primer mixes
    10244844001 AVENIO Edge UDI Adapter Kit (15 μM) 96 wells
    09200967001 AVENIO Edge HyperPure Beads Typically 24 samples per reagent set on LP,
    but up to 48 samples per reagent set on the TE side
    09200975001 AVENIO Edge HyperPlex UMI Adapter 3 x 8 reactions
    09200983001 AVENIO Edge HyperPlex UMI Adapter 3 x 24 reactions
    09200991001 AVENIO Edge HyperPlex Adapters 3 x 8 reactions
    09201009001 AVENIO Edge HyperPlex Adapters 3 x 24 reactions
    09200851001 AVENIO Edge Quantification Kit Up to 48 reactions per run
    09314512001 AVENIO Edge Solution A Kit 6 sample runs, up to 24 reactions per run
    09496386001 AVENIO Edge HyperPrep with UMI, 8 reactions Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    09496394001 AVENIO Edge HyperPrep without UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    09496408001 AVENIO Edge HyperPlus with UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    09496416001 AVENIO Edge HyperPlus without UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    09496424001 AVENIO Edge HyperPrep with UMI, 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    09496432001 AVENIO Edge HyperPrep without UMI 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    09496459001 AVENIO Edge HyperPlus with UMI, 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    09496467001 AVENIO Edge HyperPlus without UMI 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    View Full Table
    close

     

    Roche Cat. No.
    		 Description
    		 Package Size
    09056351001 AVENIO Edge Tip Park 16 tip parks
    08994609001 AVENIO Edge Processing Plate 50 plates
    09030956001 AVENIO Edge Quantification Plate 50 plates
    09031022001 AVENIO Edge Processing Plate Lid 50 lids
    09031049001 AVENIO Edge Liquid Waste Plate 60 plates
    09164081001 AVENIO Edge Tube, Panel 1 100 tubes
    09164090001 AVENIO Edge Tube, Panel 2 100 tubes
    09164103001 AVENIO Edge Tube, Panel 3 100 tubes
    09164111001 AVENIO Edge Tube, Panel 4 100 tubes
    09313630001 AVENIO Edge Pooling Tube 100 tubes
    09336320001 AVENIO Edge Pipette Tip, 50 uL 24 boxes of 96 tips (total of 2304 tips)
    09336346001 AVENIO Edge Pipette Tip, 200 uL 24 boxes of 96 tips (total of 2304 tips)
    09336354001 AVENIO Edge Pipette Tip, 1000 uL 24 boxes of 96 tips (total of 2304 tips)
    To place an order or ask a question
    Contact us

    AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

    Brochures/Flyers

    Videos

    Technical Resources

    Sarah is a lab technician who is responsible for performing many complex projects that require her full attention, including NGS library prep– not one of her favorite tasks. Sarah would love to automate her NGS workflows, but she just doesn’t have time to learn a complicated new system and optimize the workflows.

    Nate is a lab manager who orchestrates the day-to-day activities in the lab, prioritizes projects, and oversees general lab operations. Although he manages the laboratory staff, including Sarah, he sometimes joins them at the bench -- especially when project deadlines are looming. Nate is also responsible for evaluating new technologies to determine if they are a good fit for his lab, as well as ensuring that existing instrumentation is maintained.

    Kevin is an in-house automation engineer who has many years of robotics experience. He supports all the labs in his organization that operate automated liquid handlers, including Nate’s. An important part of his job is to work with both the automation vendors and the lab operators to implement and optimize new automated solutions. Kevin is an expert in what he does, but unfortunately he is the only automation specialist in the organization and there are many complex projects that require the support of an automation expert.

    AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

    ...
      ...

      For more information about the AVENIO Edge System please complete this form:

      Technician using the AVENIO Edge

      AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.